School of Molecular Sciences


Seminar schedules

All Seminars are at 3:40PM in PSH151, unless otherwise stated.

Previous Seminars


Julius Lucks
Northwestern University  
Uncovering How RNA Molecules ‘Make Decisions’ On the Fly: Towards Understanding and Engineering Cotranscriptional RNA Folding

RNAs are emerging as a powerful substrate for engineering gene expression and cellular behavior since they are now known to control almost all aspects of gene expression. As with all biomolecules, RNA function is intimately related to its structure, since RNA can adopt structures that selectively modulate gene expression. Central questions in biology and bioengineering then are: How do RNAs fold inside cells?; and How can we engineer these folds to control gene expression? In this talk, I will present our work at the interface of these two questions and share results that are beginning to uncover design principles for understanding natural RNAs and engineering RNAs for an array of applications. I will start by presenting our work on engineering RNA molecular switches that control transcription. The desire to uncover design principles for engineering these RNAs motivates our development of SHAPE-Seq, a technology that couples chemical probing with next-generation sequencing and that helps characterize RNA structures on an ‘omics’ scale. I will then describe our exciting recent developments in using SHAPE-Seq to help break open one of the frontiers of RNA structure-function relationships by uncovering at nucleotide resolution how RNAs fold cotranscriptionally. Specifically I will highlight new data on uncovering the ligand-dependent folding pathways of riboswitches, and how we are beginning to use these datasets to computationally reconstruct cotranscriptional folding pathways. This new ability is allowing us to ask deep questions about how RNA molecules make regulatory decisions ‘on the fly’ during the dynamic process of transcription. By probing the fundamental processes of RNA folding and function, these studies are expected to greatly aid RNA engineering.
Host: Petr Sulc

Jane Richardson
Early protein design, and our circuitous route to current model validation for cryoEM

Host: Jeremy Mills

Mariana Bertoni
ASU  School of Electrical, Computer and Energy Engineering
Across Dimensions and Scales: How X-ray Microscopy Can Help Design Better Solar Absorbers

Host: Marcia Levitus

Steffen Lindert
Ohio State University  
Computational Protein Structure Prediction Guided by Covalent Labeling and SID Mass Spectrometry Data

Host: Wade Van Horn
Sunney Xie
Harvard University  Department of Chemistry and Chemical Biology
Eyring General Lecture: Life at the Single Molecule Level: From Single Molecule Enzymology to Single Cell Genomics

Host: Neal Woodbury and Jia Guo

Sunney Xie
Harvard University  Department of Chemistry and Chemical Biology
Stimulated Raman Scattering Microscopy: Seeing the Invisible in Biology and Medicine

Host: Neal Woodbury and Jia Guo

Yogesh Surendranath
Bridging Molecular and Heterogeneous Catalysis Through Graphite Conjugation

Host: Gary Moore

Edgar Arriaga
University of Minnesota  Department of Chemistry
Blame it on the satellites: mass cytometric analysis of single cells

Host: Alexandra Ros

Ke Zhang
Northwestern University  

Host: Nicholas Stephanooulos

Thanksgiving-no seminar


Emily A. Carter
Eyring Lecture